Fast and broadband fiber dispersion measurement with dense wavelength sampling

We report on a method to obtain dispersion measurements from spectral-domain low-coherence interferograms which enables high accuracy (~ps/(nm·km)), broadband measurements and the determination of very dense (up to 20 points/nm over 500 nm) data sets for both dispersion and dispersion slope. The method exploits a novel phase extraction algorithm which allows the phase associated with each sampling point of the interferogram to be calculated and provides for very accurate results as well as a fast measurement capability, enabling close to real time measurements. The important issue of mitigating the measurement errors due to any residual dispersion of optical elements and to environmental fluctuations was also addressed. We performed systematic measurements on standard fibers which illustrate the accuracy and precision of the technique, and we demonstrated its general applicability to challenging problems by measuring a carefully selected set of microstructured fibers: a lead silicate W-type fiber with a flat, near-zero dispersion profile; a hollow core photonic bandgap fiber with strongly wavelength dependent dispersion and dispersion slope; a small core, highly birefringent index guiding microstructured fiber, for which polarization resolved measurements over an exceptionally wide (~1000 nm) wavelength interval were obtained

PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis

Background & Aims: Acute decompensation (AD) of cirrhosis may present without acute-on-chronic liver failure (ACLF) (ADNo ACLF), or with ACLF (AD-ACLF), defined by organ failure(s). Herein, we aimed to analyze and characterize the precipitants leading to both of these AD phenotypes. Methods: The multicenter, prospective, observational PREDICT study (NCT03056612) included 1,273 non-electively hospitalized patients with AD (No ACLF = 1,071; ACLF = 202). Medical history, clinical data and laboratory data were collected at enrolment and during 90-day follow-up, with particular attention given to the following characteristics of precipitants: induction of organ dysfunction or failure, systemic inflammation, chronology, intensity, and relationship to outcome. Results: Among various clinical events, 4 distinct events were precipitants consistently related to AD: proven bacterial infections, severe alcoholic hepatitis, gastrointestinal bleeding with shock and toxic encephalopathy. Among patients with precipitants in the AD-No ACLF cohort and the AD-ACLF cohort (38% and 71%, respectively), almost all (96% and 97%, respectively) showed proven bacterial infection and severe alcoholic hepatitis, either alone or in combination with other events. Survival was similar in patients with proven bacterial infections or severe alcoholic hepatitis in both AD phenotypes. The number of precipitants was associated with significantly increased 90day mortality and was paralleled by increasing levels of surrogates for systemic inflammation. Importantly, adequate first-line antibiotic treatment of proven bacterial infections was associated with a lower ACLF development rate and lower 90-day mortality. Conclusions: This study identified precipitants that are significantly associated with a distinct clinical course and prognosis in patients with AD. Specific preventive and therapeutic strategies targeting these events may improve outcomes in patients with decompensated cirrhosis. Lay summary: Acute decompensation (AD) of cirrhosis is characterized by a rapid deterioration in patient health. Herein, we aimed to analyze the precipitating events that cause AD in patients with cirrhosis. Proven bacterial infections and severe alcoholic hepatitis, either alone or in combination, accounted for almost all (96-97%) cases of AD and acute-on-chronic liver failure. Whilst the type of precipitant was not associated with mortality, the number of precipitant(s) was. This study identified precipitants that are significantly associated with a distinct clinical course and prognosis of patients with AD. Specific preventive and therapeutic strategies targeting these events may improve patient outcomes. (c) 2020 European Association for the Study of the Liver. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)

Dispersion controlled highly nonlinear fibers for all optical processing at telecoms wavelengths

We review our recent progress in the development of lead silicate glass fibers with high nonlinearity and tailored near-zero dispersion at telecommunication wavelengths, encompassing holey, all-solid microstructured and W-type fiber designs. The fabrication techniques and relative merits of each fiber design are described in detail. The optical properties of the fabricated fibers are assessed both experimentally and through accurate numerical simulations. The significant potential of lead silicate highly nonlinear fibers for all-optical signal processing at telecommunication wavelengths is shown via a number of key experimental demonstrators

All-solid highly nonlinear singlemode fibers with a tailored dispersion profile

We investigate a novel approach to obtain highly nonlinear fibers with a tailored group velocity dispersion around a desired wavelength region of interest. Rather than exploiting longitudinal holes to control the average refractive index of the cladding and hence the fiber's waveguide dispersion, as in holey fibers, we propose using an all-solid cladding with a suitably chosen refractive index difference relative to the core. We demonstrate numerically that this solution allows a large freedom in the manipulation of the overall fiber dispersive properties, while enabling, in practice, a much more accurate control of the fiber's structural properties during fabrication. Effectively single mode guidance over a broad wavelength range can be achieved through the use of a second outer cladding forming a W-type index profile. We derive simple design rules for dispersion controlled fibers, based on which an algorithm for the automatic dispersion optimization is proposed, implemented and used to design various nonlinear fibers for all-optical processing and supercontinuum generation. Fabrication of a lead silicate fiber with flattened dispersion at telecoms wavelengths confirms the potential of these new fibers

Fusion-spliced highly nonlinear soft-glass W-type index profiled fibre with ultra-flattened, low dispersion profile in 1.55µm telecommunication window

We report arc fusion splicing of highly nonlinear soft glass fibre with a flattened, near zero dispersion profile at 1.55µm to conventional silica fibre. Reasonable splice loss values and watt-level power handling are demonstrated

Near-zero dispersion, highly nonlinear lead-silicate W-type fiber for applications at 1.55µm

We report the design, fabrication and characterization of a lead silicate glass highly nonlinear W-type fiber with a flattened and near-zero dispersion profile in the 1.55 µm region. The fiber was composed of three types of commercial lead silicate glasses. Effectively single-mode guidance was observed in the fiber at 1550nm. The nonlinear coefficient and the propagation loss at this wavelength were measured to be 820 W-1km-1 and 2.1dB/m, respectively. Investigations of the Brillouin threshold revealed no evidence of stimulated Brillouin scattering for continuous wave signal powers up to 29dBm in a 2m sample of the fiber. A broadband dispersion measurement confirmed the near-zero dispersion values and the flat dispersion profile around 1550nm, in good agreement with our simulations. Efficient four-wave-mixing, tunable across the whole C-band, was demonstrated in a 2.2m length of the fiber

Phase regeneration of DPSK signals in a highly nonlinear lead-silicate W-type fiber

We experimentally demonstrate phase regeneration of a 40-Gb/s differential phase shift keying (DPSK) signal in a 1.7-m long highly nonlinear lead silicate W-type fiber using a degenerate two-pump phase-sensitive amplifier (PSA). Results show an improvement in the Error Vector Magnitude (EVM) and a reduction of almost a factor of 2 in the phase noise of the signal after regeneration for various noise levels at the input

Phase sensitive amplification in a highly nonlinear lead-silicate fiber

We experimentally demonstrate phase-sensitive amplification in a highly nonlinear and low-dispersion lead-silicate W-type fiber. A phase-sensitive gain variation of 6 dB was observed in a 1.56-m sample of the fiber for a total input pump power of 27.7 dBm